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The cause is particularly close to Padalecki, who has been candid about his own struggles with depression.
For the second campaign in the Always Keep Fighting series in April 2015, Padalecki partnered with co-star Jensen Ackles to release a shirt featuring both of their faces, to benefit their newly formed joint charitable fund. During San Diego Comic-Con 2015, more than 6,000 fans surprised Padalecki at the Supernatural panel by holding up candles for him, after having revealed his battle with depression earlier in the year.
He had the lead role in 2008's The Christmas Cottage as Thomas Kinkade, alongside acclaimed actor Peter O'Toole.
He also had the lead role in the 2009 version of Friday the 13th as Clay Miller, a character who heads out to Camp Crystal Lake in search of his sister who has gone missing.
Throughout the early 2000s, he appeared in several made-for-television films, including Silent Witness, Close to Home, and the Disney Channel Original Movie A Ring of Endless Light.Padalecki's engagement to his Supernatural co-star Genevieve Cortese was announced in January 2010.They met when Cortese guest starred as Ruby on the show's fourth season.Padalecki proposed to her in front of their favorite painting, "Joan of Arc", by French realist Jules Bastien-Lepage at New York's Metropolitan Museum of Art in October 2009.The pair married on February 27, 2010, in Cortese's hometown of Sun Valley, Idaho.